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The antibody against DIS3L was raised in rabbit using the Recombinant Human DIS3-like exonuclease 1 protein (1-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against DIS3L was raised in rabbit using the Recombinant Human DIS3-like exonuclease 1 protein (1-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human colon cancer using DIS3L Antibody at dilution of 1:1002
| Cat.No | ADC-25066A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DIS3L |
| Target Synonyms | DIS3L antibody; DIS3L1 antibody; KIAA1955DIS3-like exonuclease 1 antibody; EC 3.1.13.- antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human DIS3-like exonuclease 1 protein (1-300AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8TF46 |
Uniprot Id
Q8TF46
Target Species
Human
Target Name
DIS3L
Target Full Name
DIS3-like exonuclease 1
Target Function
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
Target Subcellular Location
Cytoplasm.
Target Protein Families
RNR ribonuclease family
Target Synonyms
DIS3L; DIS3L1; KIAA1955DIS3-like exonuclease 1; EC 3.1.13.-
Target Background
The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex.
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