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The antibody against DIS3L2 was raised in rabbit using the Recombinant Human DIS3-like exonuclease 2 protein (201-400AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against DIS3L2 was raised in rabbit using the Recombinant Human DIS3-like exonuclease 2 protein (201-400AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human ovarian tissue using DIS3L2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human bladder cancer using DIS3L2 Antibody at dilution of 1:1002
| Cat.No | ADC-25065A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DIS3L2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human DIS3-like exonuclease 2 protein (201-400AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IYB7 |
Uniprot Id
Q8IYB7
Target Species
Human
Target Name
DIS3L2
Target Full Name
DIS3-like exonuclease 2
Target Function
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
Target Involvement
Perlman syndrome (PRLMNS)
Target Subcellular Location
Cytoplasm. Cytoplasm, P-body.
Target Protein Families
RNR ribonuclease family, DIS3L2 subfamily
Target Synonyms
DI3L2_HUMAN; DIS3 L2; DIS3 mitotic control homolog (S. cerevisiae) like 2; DIS3 mitotic control homolog like 2; DIS3-like exonuclease 2; Dis3l2; FLJ36974; MGC42174
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