Rabbit anti-Human DLG5 Polyclonal Antibody

Uniprot Id

Q8TDM6

Target Species

Human

Target Name

DLG5

Target Full Name

Disks large homolog 5

Target Function

Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.

Target Subcellular Location

Cell junction. Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cytoplasm, cytoskeleton, cilium basal body. Note=Localized at sites of cell-cell contact.

Target Protein Families

MAGUK family

Target Tissue Specificity

Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, hea

Target Synonyms

Discs large homolog 5 (Drosophila); Discs large homolog 5; Discs large protein LP DLG; Discs large protein P dlg; Discs large protein P-dlg; Disks large homolog 5; DLG 5; DLG5; DLG5_HUMAN; KIAA0583; Large type of P DLG; LP DLG; P DLG5; PDLG; Placenta and prostate DLG