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The antibody against DLX5 was raised in rabbit using the Synthesized peptide derived from internal of Human DLX5. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against DLX5 was raised in rabbit using the Synthesized peptide derived from internal of Human DLX5. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
$297.00
Western blot analysis of extracts from HeLa cells, 293 cells and COLO205 cells, using DLX5 antibody.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using DLX5 antibody.2
| Cat.No | ADC-42016A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DLX5 |
| Target Synonyms | DLX5Homeobox protein DLX-5 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human DLX5. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P56178 |
Uniprot Id
P56178
Target Species
Human
Target Name
DLX5
Target Full Name
Homeobox protein DLX-5
Target Function
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
Target Involvement
Split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive (SHFM1D)
Target Subcellular Location
Nucleus.
Target Protein Families
Distal-less homeobox family
Target Synonyms
DLX5Homeobox protein DLX-5
Target Background
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
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