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The antibody against DMPK was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human DMPK. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against DMPK was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human DMPK. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
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Western Blot analysis of Jurkat cells using DMPK Polyclonal Antibody
Western Blot analysis of Jurkat cells using DMPK Polyclonal Antibody2
| Cat.No | ADC-38828A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DMPK |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the N-terminal region of Human DMPK. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q09013 |
Uniprot Id
Q09013
Target Species
Human
Target Name
DMPK
Target Full Name
Myotonin-protein kinase
Target Function
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Target Involvement
Dystrophia myotonica 1 (DM1)
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane. Cell membrane. Cytoplasm, cytosol.; [Isoform 1]: Mitochondrion membrane.; [Isoform 3]: Mitochondrion membrane.
Target Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family, DMPK subfamily
Target Tissue Specificity
Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, ce
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