Rabbit anti-Human DNAJB9 Polyclonal Antibody

Uniprot Id

Q9UBS3

Target Species

Human

Target Name

DNAJB9

Target Full Name

DnaJ homolog subfamily B member 9

Target Function

Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.

Target Subcellular Location

Endoplasmic reticulum lumen.

Target Tissue Specificity

Widely expressed. Expressed at highest level in the liver, placenta and kidney.

Target Synonyms

DKFZP564F1862; DnaJ (Hsp40) homolog subfamily B member 9; DnaJ homolog subfamily B member 9; DNAJB9; DNJB9_HUMAN; eEndoplasmic reticulum DNA J domain containing protein 4; Endoplasmic reticulum DnaJ homolog 4; ER resident protein ERdj4; ERdj4; MDG 1; Mdg-1; MDG1; Microvascular endothelial differentiation gene 1; Microvascular endothelial differentiation gene 1 protein; MST049; MSTP049; OTTHUMP00000206840

Target Background

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis.