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The antibody against DNASE1L3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 21-281 of human DNASE1L3 (NP_004935.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DNASE1L3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 21-281 of human DNASE1L3 (NP_004935.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04942A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DNASE1L3 |
| Target Synonyms | LSD; DHP2; SLEB16; DNAS1L3; DNASE1L3 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse spleen | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 21-281 of human DNASE1L3 (NP_004935.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13609 | Immunogen Sequence |
Uniprot Id
Q13609
Target Species
Human
Target Name
DNASE1L3
Target Full Name
Deoxyribonuclease gamma
Target Function
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity. Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation.
Target Involvement
Systemic lupus erythematosus 16 (SLEB16)
Target Subcellular Location
Nucleus. Endoplasmic reticulum. Secreted.
Target Protein Families
DNase I family
Target Tissue Specificity
Liver and spleen.
Target Research Area
Cell Biology
Target Synonyms
Deoxyribonuclease gamma; Deoxyribonuclease I like 3; Deoxyribonuclease I like III; Deoxyribonuclease I-like 3; DHP 2; DHP2; DNAS1L3; DNase gamma; DNase I homolog protein 2; DNase I homolog protein DHP2; DNase I like 3; DNase I-like 3; DNASE1L3; DNSL3_HUMAN; Liver and spleen DNase; LS DNase; LS-DNase; LSD; SLEB 16; SLEB16
Target Background
This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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