Rabbit anti-Human DNM1 Polyclonal Antibody

Uniprot Id

Q05193

Target Species

Human

Target Name

DNM1

Target Full Name

Dynamin-1

Target Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

Target Involvement

Epileptic encephalopathy, early infantile, 31 (EIEE31)

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.

Target Protein Families

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family

Target Research Area

Neuroscience

Target Synonyms

B dynamin; D100; DNM 1; DNM; DNM1; DYN1_HUMAN; Dynamin; Dynamin-1; Dynamin1

Target Background

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.