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The antibody against DNTTIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human DNTTIP1 (NP_443183.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DNTTIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human DNTTIP1 (NP_443183.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10082A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DNTTIP1 |
| Target Synonyms | Tdif1; C20orf167; dJ447F3.4; DNTTIP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Jurkat, LO2, Mouse spleen, Mouse testis, Mouse thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human DNTTIP1 (NP_443183.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H147 | Immunogen Sequence |
Uniprot Id
Q9H147
Target Species
Human
Target Name
DNTTIP1
Target Full Name
Deoxynucleotidyltransferase terminal-interacting protein 1
Target Function
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
Target Subcellular Location
Nucleus.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
C20orf167; Deoxynucleotidyltransferase terminal interacting protein 1; Deoxynucleotidyltransferase terminal-interacting protein 1; dJ447F3.4; DNTTIP1; TdIF 1; TdIF1; TDIF1_HUMAN; TdT binding protein; TdT interacting factor 1; TdT-interacting factor 1; Terminal deoxynucleotidyltransferase interacting factor 1; Terminal deoxynucleotidyltransferase-interacting factor 1
Target Background
DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).
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