Rabbit anti-Human DOK1 Monoclonal Antibody

The antibody against DOK1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 382-481 of human DOK1 (Q99704) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-14371A

Number

Cat.No	ADA-14371A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	DOK1
Target Synonyms	pp62; P62DOK; DOK1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	BxPC-3, MCF7	Application	ELISA, WB, IF/ICC

Cat.No

ADA-14371A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

DOK1

Target Synonyms

pp62; P62DOK; DOK1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

BxPC-3, MCF7

Application

ELISA, WB, IF/ICC

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 382-481 of human DOK1 (Q99704).	Target Species	Human
Immunogen Sequence	EPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST	Uniprot ID	Q99704

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 382-481 of human DOK1 (Q99704).

Target Species

Human

Immunogen Sequence

EPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST

Uniprot ID

Q99704

Background Information

Uniprot Id

Q99704
Target Species

Human
Target Name

DOK1
Target Full Name

Docking protein 1
Target Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Target Subcellular Location

[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm, perinuclear region.
Target Protein Families

DOK family, Type A subfamily
Target Tissue Specificity

Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Target Research Area

Cardiovascular
Target Synonyms

Docking protein 1 62kD ; Docking protein 1; DOK 1; DOK1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62
Target Background

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human DOK1 Monoclonal Antibody

Specifications

Immunogen Information

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