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The antibody against DPEP1 was raised in rabbit using the Recombinant Human Dipeptidase 1 protein (23-252AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against DPEP1 was raised in rabbit using the Recombinant Human Dipeptidase 1 protein (23-252AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
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Western Blot | Positive WB detected in: HT-29 whole cell lysate, A549 whole cell lysate, U87 whole cell lysate, Hela whole cell lysate | All lanes: DPEP1 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 46 kDa | Observed band size: 46 kDa
| Cat.No | ADC-00664A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DPEP1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Antigen Affinity purified & Affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Dipeptidase 1 protein (23-252AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P16444 |
Uniprot Id
P16444
Target Species
Human
Target Name
DPEP1
Target Full Name
Dipeptidase 1
Target Function
Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics.; Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.
Target Subcellular Location
Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor.
Target Protein Families
Metallo-dependent hydrolases superfamily, Peptidase M19 family
Target Tissue Specificity
Expressed in lung and kidneys.
Target Research Area
Cancer
Target Synonyms
Dehydropeptidase-I; Dipeptidase 1 (renal); Dipeptidase 1; DPEP1; DPEP1_HUMAN; hRDP; MBD1; MDP; Microsomal dipeptidase; RDP; Renal dipeptidase
Target Background
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer.
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