Rabbit anti-Human DPH1 Polyclonal Antibody

Uniprot Id

Q9BZG8

Target Species

Human

Target Name

DPH1

Target Full Name

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

Target Function

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers. Plays a role in embryonic growth, organogenesis and postnatal survival.

Target Involvement

Developmental delay with short stature, dysmorphic features, and sparse hair (DEDSSH)

Target Subcellular Location

Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization.

Target Protein Families

DPH1/DPH2 family, DPH1 subfamily

Target Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.

Target Synonyms

Candidate tumor suppressor in ovarian cancer 1; Diphthamide biosynthesis protein 1; Diphthamide biosynthesis protein 2 homolog like 1; Diphthamide biosynthesis protein 2 homolog-like 1; Diphthamide biosynthesis protein 2 like; Diphthamide biosynthesis protein 2-like; Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1; Diptheria toxin resistance protein required for diphthamide biosynthesis like 1; DPH like 1 (S. cerevisiae); DPH like 1; DPH-like 1; DPH1; DPH1 homolog (S. cerevisiae); DPH1 homolog; DPH1_HUMAN; DPH2 like 1; DPH2-like 1; DPH2L; DPH2L1; FLJ33211; HsDph1; Ovarian cancer associated gene 1; Ovarian cancer associated gene 1 protein; Ovarian cancer-associated gene 1 protein; Ovarian tumor suppressor candidate 1