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The antibody against DPP8 was raised in rabbit using the Recombinant Human Dipeptidyl peptidase 8 protein (10-230AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against DPP8 was raised in rabbit using the Recombinant Human Dipeptidyl peptidase 8 protein (10-230AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human endometrial cancer using DPP8 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using DPP8 Antibody at dilution of 1:1002
| Cat.No | ADC-44760A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DPP8 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Dipeptidyl peptidase 8 protein (10-230AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6V1X1 |
Uniprot Id
Q6V1X1
Target Species
Human
Target Name
DPP8
Target Full Name
Dipeptidyl peptidase 8
Target Function
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (Probable). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Peptidase S9B family, DPPIV subfamily
Target Tissue Specificity
Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain.
Target Synonyms
Dipeptidyl peptidase 8; Dipeptidyl peptidase IV-related protein 1; Dipeptidyl peptidase VIII; Dipeptidylpeptidase 8; DP8; DPP VIII; Dpp8; DPP8_HUMAN; DPRP-1; DPRP1; EC 3.4.14.5; MSTP141; Prolyl dipeptidase DPP8
Target Background
This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.
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