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The antibody against DRAM1 was raised in rabbit using the Recombinant Human DNA damage-regulated autophagy modulator protein 1 protein (50-100AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against DRAM1 was raised in rabbit using the Recombinant Human DNA damage-regulated autophagy modulator protein 1 protein (50-100AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human lung cancer using DRAM1 Antibody at dilution of 1:100
| Cat.No | ADC-11745A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DRAM1 |
| Target Synonyms | DRAM1; DRAM; DNA damage-regulated autophagy modulator protein 1; Damage-regulated autophagy modulator | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human DNA damage-regulated autophagy modulator protein 1 protein (50-100AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N682 |
Uniprot Id
Q8N682
Target Species
Human
Target Name
DRAM1
Target Full Name
DNA damage-regulated autophagy modulator protein 1
Target Function
Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
Target Subcellular Location
Lysosome membrane; Multi-pass membrane protein.
Target Protein Families
DRAM/TMEM150 family
Target Synonyms
DRAM1; DRAM; DNA damage-regulated autophagy modulator protein 1; Damage-regulated autophagy modulator
Target Background
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.
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