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The antibody against DRD2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human DRD2 (NP_000786.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DRD2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human DRD2 (NP_000786.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-12322A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DRD2 |
| Target Synonyms | D2R; D2DR; DRD2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | U-251MG | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DRD2 (NP_000786.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | LERQNWSRPFNGSDGK | Uniprot ID | P14416 |
Uniprot Id
P14416
Target Species
Human
Target Name
DRD2
Target Full Name
D(2) dopamine receptor
Target Function
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family
Target Tissue Specificity
[Isoform 1]: Expressed in the anterior pituitary gland.; [Isoform 2]: Expressed in the anterior pituitary gland.
Target Research Area
G-protein coupled receptor, Receptor, Transducer
Target Synonyms
DRD2; D(2 dopamine receptor; Dopamine D2 receptor
Target Background
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
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