Rabbit anti-Human DSC2 Polyclonal Antibody

Uniprot Id

Q02487

Target Species

Human

Target Name

DSC2

Target Full Name

Desmocollin-2

Target Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

Target Involvement

Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Target Tissue Specificity

Expressed in epithelia, myocardium and lymph nodes.

Target Synonyms

DG2; DSC3; CDHF2; ARVD11; DGII/III; DSC2

Target Background

This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.