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The antibody against DSG1 was raised in rabbit using the Recombinant Human Desmoglein-1 protein (384-539AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against DSG1 was raised in rabbit using the Recombinant Human Desmoglein-1 protein (384-539AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human colon cancer using DSG1 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using DSG1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-08156A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DSG1 |
| Target Synonyms | DSG1; CDHF4; Desmoglein-1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Desmoglein-1 protein (384-539AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q02413 |
Uniprot Id
Q02413
Target Species
Human
Target Name
DSG1
Target Full Name
Desmoglein-1
Target Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Target Involvement
Palmoplantar keratoderma 1, striate, focal, or diffuse (PPKS1); Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE (EPKHE)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Target Tissue Specificity
Epidermis, tongue, tonsil and esophagus.
Target Research Area
Signal Transduction
Target Synonyms
Cadherin family member 4;Desmosomal glycoprotein 1 (DG1; DGI);Pemphigus foliaceus antigen
Target Background
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.
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