Rabbit anti-Human DSPP Polyclonal Antibody

Uniprot Id

Q9NZW4

Target Species

Human

Target Name

DSPP

Target Full Name

Dentin sialophosphoprotein

Target Function

DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.

Target Involvement

Deafness, autosomal dominant, 39, with dentinogenesis imperfecta 1 (DFNA39/DGI1); Dentinogenesis imperfecta, Shields type 2 (DGI2); Dentinogenesis imperfecta, Shields type 3 (DGI3); Dentin dysplasia 2 (DTDP2)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Tissue Specificity

Expressed in teeth. DPP is synthesized by odontoblast and transiently expressed by pre-ameloblasts.

Target Synonyms

Dentin phosphophoryn; Dentin phosphoprotein; dentin phosphoryn; Dentin sialophosphoprotein; Dentin sialophosphoprotein precursor; Dentin sialoprotein; dentinogenesis imperfecta 1; DFNA39; DGI1; DMP3; DPP; DSP; Dspp; DSPP_HUMAN; DTDP2

Target Background

This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene.