Rabbit anti-Human DSTYK Polyclonal Antibody

Uniprot Id

Q6XUX3

Target Species

Human

Target Name

DSTYK

Target Full Name

Dual serine/threonine and tyrosine protein kinase

Target Function

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.

Target Involvement

Congenital anomalies of the kidney and urinary tract 1 (CAKUT1); Spastic paraplegia 23 (SPG23)

Target Subcellular Location

Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction.

Target Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family

Target Tissue Specificity

Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional

Target Synonyms

DSTYK; Dual serine/threonine and tyrosine protein kinase; Dusty PK; Dusty protein kinase; DUSTY_HUMAN; HDCMD38P; KIAA0472; Receptor interacting protein 5; Receptor interacting protein kinase 5; Receptor interacting serine/threonine protein kinase 5; Receptor-interacting serine/threonine-protein kinase 5; RIP homologous kinase; RIP-homologous kinase; RIP5; RIPK5; SgK496; Sugen kinase 496

Target Background

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene.