Rabbit anti-Human DTNA Polyclonal Antibody

Uniprot Id

Q9Y4J8

Target Species

Human

Target Name

DTNA

Target Full Name

Dystrobrevin alpha

Target Function

May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.

Target Involvement

Left ventricular non-compaction 1 (LVNC1)

Target Subcellular Location

Cytoplasm. Cell junction, synapse. Cell membrane.

Target Protein Families

Dystrophin family, Dystrobrevin subfamily

Target Tissue Specificity

Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle.

Target Synonyms

Alpha-dystrobrevin; D18S892E; DRP3; DTN; DTN-A; DTNA; DTNA_HUMAN; Dystrobrevin alpha; Dystrophin related protein 3; Dystrophin-related protein 3; FLJ96209; LVNC1; OTTHUMP00000163151; OTTHUMP00000163152; OTTHUMP00000163153; OTTHUMP00000163154; OTTHUMP00000163155

Target Background

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.