Rabbit anti-Human DUSP8 Polyclonal Antibody

Uniprot Id

Q13202

Target Species

Human

Target Name

DUSP8

Target Full Name

Dual specificity protein phosphatase 8

Target Function

Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily

Target Tissue Specificity

Abundant in brain, heart and skeletal muscle.

Target Synonyms

C11orf81; Chromosome 11 open reading frame 81 ; Deubiquitinating enzyme 8; Dual Specificity Phosphatase 8; Dual specificity phosphatase M3/6; Dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH 5; Dual specificity protein phosphatase hVH-5; DUS8; DUS8_HUMAN; DUSP8; EC 3.1.3.16; EC 3.1.3.48; FLJ42476 ; FLJ42958; H1 phosphatase vaccinia virus homolog; H1 phosphatase; vaccinia virus; homolog of; HB5; hUBPy; HVH5; HVH8; M3/6; mouse; homolog of; Neuronal tyrosine threonine phosphatase 1; Serine/threonine specific protein phosphatase ; Ubiquitin carboxyl terminal hydrolase 8; Ubiquitin specific processing protease 8; Ubiquitin thiolesterase 8; VH5

Target Background

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.