Rabbit anti-Human Dynein intermediate chain 1 Monoclonal Antibody

Uniprot Id

Q9UI46

Target Species

Human

Target Name

DNAI1

Target Full Name

Dynein axonemal intermediate chain 1

Target Function

Part of the dynein complex of respiratory cilia.

Target Involvement

Ciliary dyskinesia, primary, 1 (CILD1); Kartagener syndrome (KTGS)

Target Subcellular Location

Dynein axonemal particle. Cytoplasm, cytoskeleton, cilium axoneme.

Target Protein Families

Dynein intermediate chain family

Target Tissue Specificity

Expressed in respiratory ciliated cells (at protein level).

Target Synonyms

Axonemal dynein intermediate chain 1; Axonemal dynein intermediate chain 2; CILD 1; CILD1; Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 1; Cytoplasmic dynein intermediate chain 2; DH IC 1; DH IC 2; DIC1; DNAI 1; DNAI 2; DNAI1; DNAI1_HUMAN; DNAI2 ; DNCI 2; DNCI1 ; DNCI2; DNCIC 1; DNCIC 2; DNCIC1; DNCIC2; Dynein axonemal intermediate chain 1; Dynein axonemal intermediate polypeptide 1; Dynein axonemal intermediate polypeptide 2; Dynein cytoplasmic intermediate polypeptide 1; Dynein cytoplasmic intermediate polypeptide 2; Dynein intermediate chain 1 axonemal; Dynein intermediate chain 1 cytosolic; Dynein intermediate chain 1; axonemal; Dynein intermediate chain 2 axonemal; Dynein intermediate chain 2 cytosolic; Dynein intermediate chain DNAI1; IC74; ICS ; ICS1; Immotile cilia syndrome 1; MGC26204; PCD

Target Background

This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants.