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The antibody against E2F2 was raised in rabbit using the Peptide sequence around aa.425~429(L-F-D-S-Y) derived from Human E2F-2. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB.
The antibody against E2F2 was raised in rabbit using the Peptide sequence around aa.425~429(L-F-D-S-Y) derived from Human E2F-2. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB.
$297.00
Western blot analysis of extracts from Hela and K562 cells using E2F-2 Antibody.
| Cat.No | ADC-43101A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | E2F2 |
| Target Synonyms | dE2F2 antibody; E2F transcription factor 2 antibody; E2F-2 antibody; E2F2 antibody; E2F2_HUMAN antibody; Transcription factor E2F2 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Peptide sequence around aa.425~429(L-F-D-S-Y) derived from Human E2F-2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14209 |
Uniprot Id
Q14209
Target Species
Human
Target Name
E2F2
Target Full Name
Transcription factor E2F2
Target Function
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
Target Subcellular Location
Nucleus.
Target Protein Families
E2F/DP family
Target Tissue Specificity
Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
Target Synonyms
dE2F2; E2F transcription factor 2; E2F-2; E2F2; E2F2_HUMAN; Transcription factor E2F2
Target Background
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.
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