Rabbit anti-Human ECD Polyclonal Antibody

The antibody against ECD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 435-644 of human ECD (NP_009196.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-07988A

Number

Cat.No	ADA-07988A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ECD
Target Synonyms	GCR2; SGT1; HSGT1; ECD	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Rat brain, Mouse brain	Application	ELISA, WB

Cat.No

ADA-07988A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ECD

Target Synonyms

GCR2; SGT1; HSGT1; ECD

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Rat brain, Mouse brain

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 435-644 of human ECD (NP_009196.1).	Target Species	Human
Uniprot ID	O95905	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 435-644 of human ECD (NP_009196.1).

Target Species

Human

Uniprot ID

O95905

Immunogen Sequence

Background Information

Uniprot Id

O95905
Target Species

Human
Target Name

ECD
Target Full Name

Protein ecdysoneless homolog
Target Function

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

ECD family
Target Tissue Specificity

Highly expressed in muscle and heart. Over-expressed in pancreatic and breast cancers.
Target Synonyms

ecd; ECD_HUMAN; Ecdysoneless homolog; hSGT1; Human suppressor of GCR two; Protein ecdysoneless homolog; SGT 1; SGT1 protein; Suppressor of GCR2
Target Background

Enables histone acetyltransferase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm.

Rabbit anti-Human ECD Polyclonal Antibody

Specifications

Immunogen Information

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