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The antibody against ECSIT was raised in rabbit using the Recombinant Human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial protein (185-431AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against ECSIT was raised in rabbit using the Recombinant Human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial protein (185-431AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human small intestine tissue using ECSIT Antibody at dilution of 1:1002
| Cat.No | ADC-40526A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ECSIT |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial protein (185-431AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BQ95 |
Uniprot Id
Q9BQ95
Target Species
Human
Target Name
ECSIT
Target Full Name
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Target Function
Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.; Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Target Subcellular Location
Cytoplasm. Nucleus. Mitochondrion.
Target Protein Families
ECSIT family
Target Synonyms
Ecsit; ECSIT homolog; ECSIT protein; ECSIT_HUMAN; Evolutionarily conserved signaling intermediate in Toll pathway; mitochondrial; Evolutionarily conserved signaling intermediate in Toll pathways; Likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved; Protein SITPEC; Signaling intermediate in Toll pathway evolutionarily conserved; SITPEC; SITPEC protein
Target Background
Predicted to enable DNA-binding transcription factor activity and chromatin binding activity. Involved in regulation of oxidoreductase activity and regulation of protein complex stability. Located in cytosol; mitochondrion; and nucleoplasm.
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