Rabbit anti-Human eIF3B Polyclonal Antibody

Uniprot Id

P55884

Target Species

Human

Target Name

EIF3B

Target Full Name

Eukaryotic translation initiation factor 3 subunit B

Target Function

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.; (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2

Target Subcellular Location

Cytoplasm.

Target Protein Families

EIF-3 subunit B family

Target Synonyms

eIF-3-eta; eIF3 eta; eIF3 p110; eIF3 p116; EIF3-ETA; EIF3-P110; EIF3-P116; eIF3b; EIF3B_HUMAN; EIF3S9; EIF3S9; formerly; Eukaryotic translation initiation factor 3; subunit B; Eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3 subunit 9 eta; Eukaryotic translation initiation factor 3 subunit B; eukaryotic translation initiation factor 3; subunit 9 (eta; 116kD); eukaryotic translation initiation factor 3; subunit 9 eta; 116kDa; eukaryotic translation initiation factor 3; subunit 9; formerly; hPrt1; Protein synthesis defective at 36 degrees celsius 1; S. cerevisiae; homolog of; PRT1; Prt1 homolog