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The antibody against EIF4G3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1000-1200 of human EIF4G3 (NP_003751.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against EIF4G3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1000-1200 of human EIF4G3 (NP_003751.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05536A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EIF4G3 |
| Target Synonyms | eIF4G 3; eIF4GII; eIF-4G 3; EIF4G3 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, LO2 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1200 of human EIF4G3 (NP_003751.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O43432 | Immunogen Sequence |
Uniprot Id
O43432
Target Species
Human
Target Name
EIF4G3
Target Full Name
Eukaryotic translation initiation factor 4 gamma 3
Target Function
Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.
Target Protein Families
Eukaryotic initiation factor 4G family
Target Synonyms
eIF-4-gamma 3; eIF-4-gamma II; eIF-4G 3; eIF4G 3; EIF4G3; eIF4GII; Eukaryotic translation initiation factor 4 gamma 3; eukaryotic translation initiation factor 4 gamma; 3; eukaryotic translation initiation factor-4 gamma; 3; IF4G3_HUMAN
Target Background
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p.
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