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The antibody against EME1 was raised in rabbit using the Recombinant Human Crossover junction endonuclease EME1 protein (1-583AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against EME1 was raised in rabbit using the Recombinant Human Crossover junction endonuclease EME1 protein (1-583AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human endometrial cancer using EME1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using EME1 Antibody at dilution of 1:1002
| Cat.No | ADC-44198A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EME1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Crossover junction endonuclease EME1 protein (1-583AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96AY2 |
Uniprot Id
Q96AY2
Target Species
Human
Target Name
EME1
Target Full Name
Crossover junction endonuclease EME1
Target Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Target Subcellular Location
Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells.
Target Protein Families
EME1/MMS4 family
Target Research Area
Cell Biology
Target Synonyms
6820428D13; Crossover junction endonuclease EME1; EC 3.1.22.-; EME1; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe); EME1; S. pombe; homolog of; 1; EME1_HUMAN; essential meiotic endonuclease 1 homolog 1 (S pombe); Essential Meiotic Endonuclease 1 Homolog 1; essential meiotic endonuclease 1 homolog 2; Essential meiotic endonuclease 1; S. pombe; homolog of; 1; FLJ31364; hMMS4; homolog of yeast EME1 endonuclease; MGC106543; MMS4 ; MMS4 homolog; MMS4L
Target Background
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.
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