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The antibody against EMP2 was raised in rabbit using the Synthetic peptide of Human EMP2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against EMP2 was raised in rabbit using the Synthetic peptide of Human EMP2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-26781A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EMP2 |
| Target Synonyms | EMP2; XMP; Epithelial membrane protein 2; EMP-2; Protein XMP | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human EMP2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P54851 |
Uniprot Id
P54851
Target Species
Human
Target Name
EMP2
Target Full Name
Epithelial membrane protein 2
Target Function
Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity. Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion. Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation. Regulates cell migration and cell contraction through PTK2 and SRC activation. Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2. Positively regulates cell proliferation. Plays a role during cell death and cell blebbing. Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway. Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3. May play a role in glomerular filtration.
Target Involvement
Nephrotic syndrome 10 (NPHS10)
Target Subcellular Location
Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane. Apical cell membrane. Membrane raft. Cytoplasm. Nucleus.
Target Protein Families
PMP-22/EMP/MP20 family
Target Tissue Specificity
Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level).
Target Synonyms
EMP2; XMP; Epithelial membrane protein 2; EMP-2; Protein XMP
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