Rabbit anti-Human Epac1/RAPGEF3 Polyclonal Antibody

The antibody against Epac1/RAPGEF3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Epac1/Epac1/RAPGEF3 (NP_001092002.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-04386A

Number

Cat.No	ADA-04386A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Epac1/RAPGEF3
Target Synonyms	EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI; Epac1/RAPGEF3	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse heart, Mouse thymus	Application	ELISA, WB

Cat.No

ADA-04386A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Epac1/RAPGEF3

Target Synonyms

EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI; Epac1/RAPGEF3

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse heart, Mouse thymus

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Epac1/Epac1/RAPGEF3 (NP_001092002.1).	Target Species	Human
Immunogen Sequence	MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLH	Uniprot ID	O95398

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Epac1/Epac1/RAPGEF3 (NP_001092002.1).

Target Species

Human

Immunogen Sequence

MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLH

Uniprot ID

O95398

Background Information

Uniprot Id

O95398
Target Species

Human
Target Name

RAPGEF3
Target Full Name

Rap guanine nucleotide exchange factor 3
Target Function

Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Target Subcellular Location

Endomembrane system.
Target Tissue Specificity

Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Target Synonyms

RAPGEF3; CGEF1; EPAC; EPAC1; Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI
Target Background

Enables guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in several processes, including positive regulation of protein modification process; regulation of actin cytoskeleton organization; and regulation of syncytium formation by plasma membrane fusion. Located in filopodium; lamellipodium; and microvillus. Colocalizes with cortical actin cytoskeleton and plasma membrane. Biomarker of congestive heart failure.

Rabbit anti-Human Epac1/RAPGEF3 Polyclonal Antibody

Specifications

Immunogen Information

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