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The antibody against EPB41 was raised in rabbit using the Peptide sequence around phosphorylation site of tyrosine 660/418 (N-I-Y(p)-I-R)derived from Human EPB41. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB.
The antibody against EPB41 was raised in rabbit using the Peptide sequence around phosphorylation site of tyrosine 660/418 (N-I-Y(p)-I-R)derived from Human EPB41. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from HepG2 cells treated with PMA using EPB41 (Phospho-Tyr660/418) Antibody.The lane on the right is treated with the antigen-specific peptide.
| Cat.No | ADC-42687A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EPB41 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Peptide sequence around phosphorylation site of tyrosine 660/418 (N-I-Y(p)-I-R)derived from Human EPB41. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P11171 |
Uniprot Id
P11171
Target Species
Human
Target Name
EPB41
Target Full Name
Protein 4.1
Target Function
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Target Involvement
Elliptocytosis 1 (EL1)
Target Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Nucleus.
Target Synonyms
4.1R; 41_HUMAN; Band 4.1; E41P; EL 1; EL1; EL1 gene; Elliptocytosis 1; Elliptocytosis 1 RH linked; EPB 4.1; EPB 41; EPB4.1; Epb41; Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked); Erythrocyte membrane protein band 4.1; Erythrocyte surface protein band 4.1; HE; P4.1; Protein 4.1; Protein 4.1; red blood cell type
Target Background
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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