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The antibody against EPPK1 was raised in rabbit using the Recombinant Human Epiplakin protein (1-225AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against EPPK1 was raised in rabbit using the Recombinant Human Epiplakin protein (1-225AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-50212A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EPPK1 |
| Target Synonyms | 450 kDa epidermal antigen antibody; Epidermal autoantigen 450K antibody; EPIPL antibody; EPIPL_HUMAN antibody; EPIPL1 antibody; Epiplakin antibody; EPPK1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Epiplakin protein (1-225AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P58107 |
Uniprot Id
P58107
Target Species
Human
Target Name
EPPK1
Target Full Name
Epiplakin
Target Function
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell junction, hemidesmosome. Cell junction, tight junction. Cell projection. Apicolateral cell membrane. Basolateral cell membrane. Cell junction.
Target Protein Families
Plakin or cytolinker family
Target Tissue Specificity
Expressed in epithelial cells of liver, small intestine, colon, salivary glands, stomach and appendix.
Target Research Area
Signal Transduction
Target Synonyms
450 kDa epidermal antigen; Epidermal autoantigen 450K; EPIPL; EPIPL_HUMAN; EPIPL1; Epiplakin; EPPK1
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