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The antibody against ERBIN was raised in rabbit using the Recombinant Human Erbin protein (1193-1412AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against ERBIN was raised in rabbit using the Recombinant Human Erbin protein (1193-1412AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human melanoma using ERBIN Antibody at dilution of 1:1002
| Cat.No | ADC-16272A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ERBIN |
| Target Synonyms | Densin-180-like protein antibody; Erbb2-interacting protein antibody; Erbb2ip antibody; Erbin antibody; LAP2 antibody; LAP2_HUMAN antibody; Protein LAP2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Erbin protein (1193-1412AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96RT1 |
Uniprot Id
Q96RT1
Target Species
Human
Target Name
ERBIN
Target Full Name
Erbin
Target Function
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion.
Target Subcellular Location
Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane.
Target Protein Families
LAP (LRR and PDZ) protein family
Target Tissue Specificity
Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
Target Synonyms
Densin-180-like protein; Erbb2-interacting protein; Erbb2ip; Erbin; LAP2; LAP2_HUMAN; Protein LAP2
Target Background
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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