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The antibody against ERCC6L2 was raised in rabbit using the Recombinant Human DNA excision repair protein ERCC-6-like 2 protein (72-371AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against ERCC6L2 was raised in rabbit using the Recombinant Human DNA excision repair protein ERCC-6-like 2 protein (72-371AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human lung tissue using ERCC6L2 Antibody at dilution of 1:100
| Cat.No | ADC-22197A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ERCC6L2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human DNA excision repair protein ERCC-6-like 2 protein (72-371AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q5T890 |
Uniprot Id
Q5T890
Target Species
Human
Target Name
ERCC6L2
Target Full Name
DNA excision repair protein ERCC-6-like 2
Target Function
May be involved in early DNA damage response.
Target Involvement
Bone marrow failure syndrome 2 (BMFS2)
Target Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mitochondrion. Note=Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner.
Target Protein Families
SNF2/RAD54 helicase family
Target Tissue Specificity
Expressed in bone marrow (at protein level).
Target Synonyms
C9orf102; Chromosome 9 open reading frame 102; excision repair cross-complementing rodent repair deficiency; complementation group 6-like 2; FLJ37706; MGC30192; MGC43364; Putative DNA repair and recombination protein RAD26-like; putative repair and recombination helicase RAD26L; RAD26_HUMAN; Rad26l; RAD26L hypothetical protein; SR278; stretch responsive protein 278
Target Background
This gene encodes a member of the Snf2 family of helicase-like proteins. The encoded protein may play a role in DNA repair and mitochondrial function. Mutations in this gene have been associated with bone marrow failure syndrome 2. Alternatively spliced transcript variants that encode different protein isoforms have been described.
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