Rabbit anti-Human ERVFRD-1 Polyclonal Antibody

Uniprot Id

P60508

Target Species

Human

Target Name

ERVFRD-1

Target Full Name

Syncytin-2

Target Function

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process.; Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.

Target Subcellular Location

Virion.; [Surface protein]: Cell membrane; Peripheral membrane protein.; [Transmembrane protein]: Cell membrane; Single-pass membrane protein.

Target Protein Families

Gamma type-C retroviral envelope protein family, HERV class-I FRD env subfamily

Target Tissue Specificity

Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.

Target Research Area

Cancer

Target Synonyms

EFRD1_HUMAN; Endogenous retrovirus group FRD member 1; Envelope polyprotein; ERVFRD-1; FLJ41944; FLJ90611; GLLL6191; HERV FRD 6p24.1 provirus ancestral Env polyprotein; HERV FRD; HERV FRD provirus ancestral Env polyprotein; HERV-FRD; HERVFRD; HERVFRD provirus ancestral Env polyprotein; MGC87585; SU; Syncytin 2; Syncytin B; Syncytin-2; TM; Transmembrane protein; UNQ6191

Target Background

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.