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The antibody against ESYT2 was raised in rabbit using the Recombinant Human Extended synaptotagmin-2 protein (567-736AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against ESYT2 was raised in rabbit using the Recombinant Human Extended synaptotagmin-2 protein (567-736AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-06937A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ESYT2 |
| Target Synonyms | ESYT2 antibody; FAM62B antibody; KIAA1228Extended synaptotagmin-2 antibody; E-Syt2 antibody; Chr2Syt antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Extended synaptotagmin-2 protein (567-736AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | A0FGR8 |
Uniprot Id
A0FGR8
Target Species
Human
Target Name
ESYT2
Target Full Name
Extended synaptotagmin-2
Target Function
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS).
Target Subcellular Location
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
Extended synaptotagmin family
Target Tissue Specificity
Widely expressed with high level in cerebellum.
Target Research Area
Cell Biology
Target Synonyms
ESYT2; FAM62B; KIAA1228Extended synaptotagmin-2; E-Syt2; Chr2Syt
Target Background
Enables calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endocytosis; endoplasmic reticulum-plasma membrane tethering; and lipid transport. Located in endoplasmic reticulum-plasma membrane contact site. Is extrinsic component of cytoplasmic side of plasma membrane; integral component of plasma membrane; and intrinsic component of endoplasmic reticulum membrane.
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