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The antibody against ETV6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against ETV6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-09982A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ETV6 |
| Target Synonyms | TEL; THC5; TEL/ABL; ETV6 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, Jurkat, K-562, Mouse ovary, Rat kidney, Rat lung | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P41212 | Immunogen Sequence |
Uniprot Id
P41212
Target Species
Human
Target Name
ETV6
Target Full Name
Transcription factor ETV6
Target Function
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
Target Involvement
Myeloproliferative disorder chronic with eosinophilia (MPE); Leukemia, acute myelogenous (AML); Thrombocytopenia 5 (THC5)
Target Subcellular Location
Nucleus.
Target Protein Families
ETS family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
ETS related protein Tel1; ETS translocation variant 6; Ets variant 6; Ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; ETV 6; ETV6; ETV6_HUMAN; Tel; TEL oncogene; TEL/ABL; TEL1; TEL1 oncogene; Transcription factor ETV 6; Transcription factor ETV6
Target Background
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
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