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The antibody against EVC was raised in rabbit using the Recombinant Human Ellis-van Creveld syndrome protein (493-602AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against EVC was raised in rabbit using the Recombinant Human Ellis-van Creveld syndrome protein (493-602AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry analysis of human pancreatic cancer using EVC Antibody at dilution of 1:1002
| Cat.No | ADC-09173A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EVC |
| Target Synonyms | EVCEllis-van Creveld syndrome protein antibody; DWF-1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ellis-van Creveld syndrome protein (493-602AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P57679 |
Uniprot Id
P57679
Target Species
Human
Target Name
EVC
Target Full Name
EvC complex member EVC
Target Function
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.
Target Involvement
Ellis-van Creveld syndrome (EVC); Acrofacial dysostosis, Weyers type (WAD)
Target Subcellular Location
Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cell projection, cilium membrane.
Target Tissue Specificity
Found in the developing vertebral bodies, ribs, upper and lower limbs, heart, kidney, lung.
Target Synonyms
EVCEllis-van Creveld syndrome protein; DWF-1
Target Background
This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis.
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