Rabbit anti-Human EWSR1 Polyclonal Antibody

Uniprot Id

Q01844

Target Species

Human

Target Name

EWSR1

Target Full Name

RNA-binding protein EWS

Target Function

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Target Involvement

Ewing sarcoma (ES); Angiomatoid fibrous histiocytoma (AFH)

Target Subcellular Location

Nucleus. Cytoplasm. Cell membrane. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.

Target Protein Families

RRM TET family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

EWS; EWS-FLI1; bK984G1.4; EWSR1

Target Background

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.