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The antibody against EXT2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human EXT2 (NP_000392.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against EXT2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human EXT2 (NP_000392.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09924A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EXT2 |
| Target Synonyms | SOTV; SSMS; EXT2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HT-1080, Mouse liver, Rat kidney, SKOV3, SW480, U-87MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human EXT2 (NP_000392.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q93063 | Immunogen Sequence |
Uniprot Id
Q93063
Target Species
Human
Target Name
EXT2
Target Full Name
Exostosin-2
Target Function
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan.
Target Involvement
Hereditary multiple exostoses 2 (EXT2); Potocki-Shaffer syndrome (POSHS); Seizures, scoliosis, and macrocephaly syndrome (SSMS)
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Target Protein Families
Glycosyltransferase 47 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Exostoses (multiple) 2; Exostosin 2; Exostosin-2; EXT2; EXT2_HUMAN; Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 2; N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase; Putative tumor suppressor protein EXT2; SOTV
Target Background
This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
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