Rabbit anti-Human EYA2 Polyclonal Antibody

The antibody against EYA2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 300-400 of human EYA2 (NP_005235.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-05293A

Number

Cat.No	ADA-05293A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	EYA2
Target Synonyms	EAB1; EYA2	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, A-549	Application	ELISA, WB

Cat.No

ADA-05293A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

EYA2

Target Synonyms

EAB1; EYA2

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, A-549

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 300-400 of human EYA2 (NP_005235.3).	Target Species	Human
Immunogen Sequence	TSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGG	Uniprot ID	O00167

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human EYA2 (NP_005235.3).

Target Species

Human

Immunogen Sequence

TSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGG

Uniprot ID

O00167

Background Information

Uniprot Id

O00167
Target Species

Human
Target Name

EYA2
Target Full Name

Protein phosphatase EYA2
Target Function

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

HAD-like hydrolase superfamily, EYA family
Target Tissue Specificity

Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

EAB 1; EAB1; EYA 2; EYA transcriptional coactivator and phosphatase 2; EYA2; EYA2_HUMAN; eyes absent 2 homolog (Drosophila); Eyes absent homolog 2 (Drosophila); Eyes absent homolog 2; Translation of this uORF probably lowers the translation efficiency of EYA2
Target Background

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.

Rabbit anti-Human EYA2 Polyclonal Antibody

Specifications

Immunogen Information

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