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The antibody against EYA4 was raised in rabbit using the Recombinant Human Eyes absent homolog 4 protein (153-224AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against EYA4 was raised in rabbit using the Recombinant Human Eyes absent homolog 4 protein (153-224AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-06077A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EYA4 |
| Target Synonyms | CMD1J antibody; Deafness | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Eyes absent homolog 4 protein (153-224AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95677 |
Uniprot Id
O95677
Target Species
Human
Target Name
EYA4
Target Full Name
Protein phosphatase EYA4
Target Function
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
Target Involvement
Deafness, autosomal dominant, 10 (DFNA10); Cardiomyopathy, dilated 1J (CMD1J)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
HAD-like hydrolase superfamily, EYA family
Target Tissue Specificity
Highly expressed in heart and skeletal muscle.
Target Synonyms
CMD1J; Deafness, autosomal dominant 10; DFNA 10; DFNA10; dJ78N10.1 (eyes absent (Drosophila) homolog 4); dJ78N10.1 (eyes absent); EYA 4; eya4; EYA4_HUMAN; Eyes absent 4; Eyes absent homolog 4 (Drosophila) ; Eyes absent homolog 4; HGNC:3522; OTTHUMP00000040267
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