Rabbit anti-Human F7 Polyclonal Antibody

Uniprot Id

P08709

Target Species

Human

Target Name

F7

Target Full Name

Coagulation factor VII

Target Function

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

Target Involvement

Factor VII deficiency (FA7D)

Target Subcellular Location

Secreted.

Target Protein Families

Peptidase S1 family

Target Tissue Specificity

Plasma.

Target Research Area

Cardiovascular

Target Synonyms

coagulation factor VII (serum prothrombin conversion accelerator); Coagulation factor VII; Eptacog alfa ; F7; FA7_HUMAN; Factor VII ; Factor VII heavy chain; Factor VII light chain; FVII coagulation protein ; OTTHUMP00000018733; OTTHUMP00000018734; Proconvertin; Serum prothrombin conversion accelerator; SPCA

Target Background

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.