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The antibody against F8 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human Factor VIII. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against F8 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human Factor VIII. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
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Western Blot analysis of HuvEc cells using Factor VIII Polyclonal Antibody
Western Blot analysis of HuvEc cells using Factor VIII Polyclonal Antibody2
| Cat.No | ADC-38701A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | F8 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human Factor VIII. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P00451 |
Uniprot Id
P00451
Target Species
Human
Target Name
F8
Target Full Name
Coagulation factor VIII
Target Function
Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.
Target Involvement
Hemophilia A (HEMA)
Target Subcellular Location
Secreted, extracellular space.
Target Protein Families
Multicopper oxidase family
Target Research Area
Others
Target Synonyms
AHF; Antihemophilic factor; Coagulation factor VIII; coagulation factor VIII; procoagulant component; coagulation factor VIIIc; DXS1253E; F8; F8b; F8c; FA8_HUMAN; factor VIII F8B; Factor VIIIa light chain; FactorVIII; FVIII; Hema; Hemophilia A; Hemophilia; classic; OTTHUMP00000061446; OTTHUMP00000196174; Procoagulant component
Target Background
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
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