Rabbit anti-Human FAM107A Polyclonal Antibody

Uniprot Id

O95990

Target Species

Human

Target Name

FAM107A

Target Full Name

Actin-associated protein FAM107A

Target Function

Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory. Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development.

Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Cell projection, ruffle membrane. Cell junction, synapse.

Target Protein Families

FAM107 family

Target Tissue Specificity

Widely expressed. Expressed in neurons. Expressed in malignant glial tumors. Expression is reduced or absent in a number of cancer cell lines.

Target Synonyms

Down regulated in renal cell carcinoma 1; Down-regulated in renal cell carcinoma 1; Downregulated in renal cell carcinoma; DRR1; F107A_HUMAN; FAM107A; Family with sequence similarity 107; member A ; FLJ30158 ; FLJ45473; Protein FAM107A; Protein TU3A; TU3A

Target Background

Predicted to enable actin binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of focal adhesion assembly; and regulation of cytoskeleton organization. Located in several cellular components, including focal adhesion; ruffle membrane; and stress fiber.