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The antibody against FAM89B was raised in rabbit using the Recombinant Human Leucine repeat adapter protein 25 protein (1-162AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against FAM89B was raised in rabbit using the Recombinant Human Leucine repeat adapter protein 25 protein (1-162AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-18577A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FAM89B |
| Target Synonyms | FAM89B antibody; Lrap25 antibody; Leucine repeat adapter protein 25 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Leucine repeat adapter protein 25 protein (1-162AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N5H3 |
Uniprot Id
Q8N5H3
Target Species
Human
Target Name
FAM89B
Target Full Name
Leucine repeat adapter protein 25
Target Function
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Target Subcellular Location
[Isoform 3]: Cytoplasm. Cell projection, lamellipodium.
Target Protein Families
FAM89 family
Target Synonyms
FAM89B; Lrap25; Leucine repeat adapter protein 25
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