Rabbit anti-Human FANCG Polyclonal Antibody

Uniprot Id

O15287

Target Species

Human

Target Name

FANCG

Target Full Name

Fanconi anemia group G protein

Target Function

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.

Target Involvement

Fanconi anemia complementation group G (FANCG)

Target Subcellular Location

Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.

Target Tissue Specificity

Highly expressed in testis and thymus. Found in lymphoblasts.

Target Synonyms

DNA repair protein XRCC9; FAG; FANCG; FANCG_HUMAN; Fanconi anaemia complementation group G; Fanconi anemia group G protein; Protein FACG; X ray repair; complementing defective; in Chinese hamster cells 9; X-ray repair; complementing defective; in Chinese hamster; 9; XRCC9

Target Background

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G.