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The antibody against FBXL12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human FBXL12 (NP_060173.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FBXL12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human FBXL12 (NP_060173.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10196A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FBXL12 |
| Target Synonyms | Fbl12; FBXL12 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, NIH/3T3, 293T, A-431, SW480 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human FBXL12 (NP_060173.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NXK8 | Immunogen Sequence |
Uniprot Id
Q9NXK8
Target Species
Human
Target Name
FBXL12
Target Full Name
F-box/LRR-repeat protein 12
Target Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
Target Synonyms
F box and leucine rich repeat protein 12; F box protein FBL12; F box/LRR repeat protein 12; F-box and leucine-rich repeat protein 12; F-box protein FBL12; F-box/LRR-repeat protein 12; Fbl12; FBXL 12; FBXL12; FLJ20188; FXL12_HUMAN
Target Background
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
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