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The antibody against FBXL14 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human FBXL14 (NP_689654.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FBXL14 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human FBXL14 (NP_689654.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07146A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FBXL14 |
| Target Synonyms | Fbl14; FBXL14 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-431, HepG2, Mouse brain, Mouse spleen, Mouse thymus, Rat thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human FBXL14 (NP_689654.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8N1E6 | Immunogen Sequence |
Uniprot Id
Q8N1E6
Target Species
Human
Target Name
FBXL14
Target Full Name
F-box/LRR-repeat protein 14
Target Function
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.
Target Subcellular Location
Cytoplasm.
Target Synonyms
FBXL14; FBL14F-box/LRR-repeat protein 14; F-box and leucine-rich repeat protein 14
Target Background
Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
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