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The antibody against FBXL21 was raised in rabbit using the Recombinant Human F-box/LRR-repeat protein 21 protein (78-137AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against FBXL21 was raised in rabbit using the Recombinant Human F-box/LRR-repeat protein 21 protein (78-137AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human lung cancer using FBXL21 Antibody at dilution of 1:1002
| Cat.No | ADC-14897A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FBXL21 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human F-box/LRR-repeat protein 21 protein (78-137AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UKT6 |
Uniprot Id
Q9UKT6
Target Species
Human
Target Name
FBXL21P
Target Full Name
Putative F-box/LRR-repeat protein 21
Target Function
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
Target Subcellular Location
Cytoplasm, cytosol. Nucleus.
Target Synonyms
F box and leucine rich repeat protein 21; F box and leucine rich repeat protein 3 pseudogene; F box and leucine rich repeat protein 3B; F box protein Fbl3b; F box/LRR repeat protein 21; F box/LRR repeat protein 3B; F-box and leucine-rich repeat protein 21; F-box and leucine-rich repeat protein 3B; F-box/LRR-repeat protein 21; F-box/LRR-repeat protein 3B; Fbl 21; FBL 3; FBL 3B; Fbl21; FBL3; FBL3B; FBXL 21; FBXL 3B; FBXL 3P; Fbxl21; FBXL3B; FBXL3P; FXL21_HUMAN; MGC120237
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